ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE
• CAS No.: 500011-88-1
• Molecular Formula: C11H12ClN3O3
• Molecular Weight: 269.688
• Mol file: 500011-88-1.mol

Synonyms:ethyl 2-(3-chloro-2-pyridinyl)-5-oxopyrazolidine-3-carboxylate;ethyl 2-(3-chloro-2-pyridinyl)-5-oxo-3-pyrazolidine-carboxylate;2-(3-chloro-pyridin-2-yl)-5-oxopyrazolidine-3-carboxylic acid ethyl ester;ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE;2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester;ethyl 2-(3-chloro-2-pyridinyl)-5-oxo-3-pyrazolidinecarboxylate;ethyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate;

Chemical Property of ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0-0Pa at 20-50℃
• Melting Point: 132-134 °C
• PKA: 10.77±0.40(Predicted)
• PSA: 75.02000
• Density: 1.377±0.06 g/cm3(Predicted)
• LogP: 1.24890

Purity/Quality:

99.9% ^*data from raw suppliers

95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE

There total 16 articles about ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3-chloro-2-pyridyl)hydrazine (22841-92-5) + but-2-enedioic acid diethyl ester (1520-50-9) → 2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester (500011-88-1)

Guidance literature:

With nickel hexafluoroacetylacetonate; potassium etoxide; In ethanol; at 40 ℃; for 4h; Temperature; Reagent/catalyst;

Reference yield: 90.0%

5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester (500011-91-6) → 2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester (500011-88-1)

Guidance literature:

5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester; With sulfuric acid; In acetonitrile; at 22 - 36 ℃;

With potassium peroxodisulfate; at 84 ℃; for 2h;

Reference yield: 85.0%

ethyl 4-[2-(3-chloropyridin-2-yl)hydrazinyl]-4-oxobut-2-enoate → 2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester (500011-88-1)

Guidance literature:

With bis(tricyclohexylphosphine)nickel dichloride; sodium ethanolate; In ethanol; at 50 ℃; for 8h;

upstream raw materials:

(3-chloro-2-pyridyl)hydrazine

Diethyl maleate

ethanol

sodium ethanolate

Downstream raw materials:

5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester

3-chloro-N-(4-chloro-2-((5-(diethylamino)pentan-2-yl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

3-bromo-N-(4-chloro-2-((5-(diethylamino)pentan-2-yl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide