4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Base Information

Chemical Name:4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
CAS No.:1334679-09-2
Molecular Formula:C₂₀H₂₇NO₆
Molecular Weight:377.437
Hs Code.:

Synonyms:4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

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Chemical Property of 4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Chemical Property:

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Technology Process of 4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

There total 3 articles about 4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334679-08-1
4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

: 1334679-09-2
4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 5h; under 2585.81 Torr;

Reference yield:

: 177990-33-9
4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine

: 1334679-09-2
4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 5 h / 20 °C / 2585.81 Torr

With hydrogen; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; n-heptane; ethylbenzene;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1334679-09-2
4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 5 h / 20 °C / 2585.81 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethylbenzene;