Benzyl N-Boc-4-piperidinecarboxylate

Base Information

• Chemical Name: Benzyl N-Boc-4-piperidinecarboxylate
• CAS No.: 177990-33-9
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.401
• Hs Code.: 2933399090
• Mol file: 177990-33-9.mol

Synonyms:Benzyl 1-tert-butyloxycarbonylpiperidine-4-carboxylate;benzyl N-tert-butoxycarbonylisonipecotate;4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine;piperidine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester;Benzyl N-Boc-4-piperidinecarboxylate;

Chemical Property of Benzyl N-Boc-4-piperidinecarboxylate

Chemical Property:

• Boiling Point: 415.5±38.0 °C(Predicted)
• PKA: -2.31±0.40(Predicted)
• PSA: 55.84000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 3.31480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

BenzylN-Boc-4-piperidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl N-Boc-4-piperidinecarboxylate

There total 9 articles about Benzyl N-Boc-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl chloride (100-44-7) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine (177990-33-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

Reference yield: 95.0%

benzyl bromide (100-39-0) → 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine (177990-33-9)

Guidance literature:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With caesium carbonate; In methanol; at 20 ℃; for 2h;

benzyl bromide; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield: 83.0%

benzyl bromide (100-39-0) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine (177990-33-9)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating / reflux;

upstream raw materials:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

benzyl alcohol

benzyl bromide

tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate

Downstream raw materials:

(3S,4S)-N-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

(1,2-bis(4-methoxyphenyl)-2-oxoethyl) 4-benzyloxycarbonyl-1-tert-butoxycarbonyl-4-piperidinecarboxylate