(2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

Base Information

• Chemical Name: (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid
• CAS No.: 1426573-07-0
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415
• Mol file: 1426573-07-0.mol

Synonyms:(2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

Chemical Property of (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

There total 38 articles about (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid methyl ester dihydrochloride → (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid (1426573-07-0)

Guidance literature:

(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid methyl ester dihydrochloride; With sodium hydroxide; In 1,4-dioxane; water; for 1h; Cooling with ice;

di-tert-butyl dicarbonate; With hydrogenchloride; potassium carbonate; In 1,4-dioxane; water; at 20 ℃;

Reference yield: 100.0%

(2S,5R)-5-(benzyloxyamino)piperidin-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester → (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid (1426573-07-0)

Guidance literature:

With water; lithium hydroxide; In acetone; at 0 - 20 ℃; for 5h;

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxylic acid → (2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid (1426573-07-0)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 0 - 20 ℃; Temperature;

upstream raw materials:

di-tert-butyl dicarbonate

(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

(2S)-5-oxopiperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Downstream raw materials:

trans-2-(5-methyl[1,3,4]thiadiazol-2-yl)-5-(benzyloxyamino)piperidine-1-carboxylic acid tert-butyl ester

trans-2-(5-methyl[1,3,4]thiadiazol-2-yl)-5-(benzyloxyamino)piperidine

2-(5-methyl[1,3,4]thiadiazol-2-yl)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octane

trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester