trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester
CAS No.:1426572-83-9
Molecular Formula:C₁₈H₂₇N₃O₄
Molecular Weight:349.43
Hs Code.:

Synonyms:trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

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Technology Process of trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

There total 11 articles about trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1426573-07-0
(2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

: 1426572-83-9
trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; Solvent; Reagent/catalyst; Cooling with ice;

Reference yield:

: C₂₃H₃₄N₂O₆

: 1426572-83-9
trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With ammonia; In dichloromethane; at -40 ℃; for 0.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1426572-83-9
trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h

1.2: 0.5 h / 5 - 10 °C

1.3: 16 h / 5 - 20 °C

2.1: lithium hydroxide; water / acetone / 5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 °C

4.1: ammonia / dichloromethane / 0.5 h / -40 °C

With ammonia; water; sodium hydrogencarbonate; triethylamine; lithium hydroxide; In dichloromethane; water; ethyl acetate; acetone;