N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Base Information

• Chemical Name: N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
• CAS No.: 1361330-06-4
• Molecular Formula: C₂₇H₂₉FN₄O₅S
• Molecular Weight: 540.615
• Mol file: 1361330-06-4.mol

Synonyms:N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Chemical Property of N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

There total 8 articles about N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-{[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-53-1) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-06-4)

Guidance literature:

With methanol; potassium carbonate; for 2h; Inert atmosphere;

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) + 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate (1361330-48-4) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-06-4)

Guidance literature:

4-Fluorobenzenesulfonyl chloride; 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate; With pyridine; In dichloromethane; at 20 ℃; for 0.55h;

With methanol; potassium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/jm301572h

Reference yield:

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide (1361330-06-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 21 h / 21 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

3: triethylamine / dichloromethane / 2 h / Inert atmosphere

4: potassium carbonate; methanol / 2 h / Inert atmosphere

With pyridine; methanol; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

2-{[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate