tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate
CAS No.:1338349-27-1
Molecular Formula:C₂₃H₃₅FN₂O₃
Molecular Weight:406.541
Hs Code.:

Synonyms:tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184085-37-7
C₁₂H₁₄FN

: 1338349-27-1
tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide; hydrogen / ethanol / 20 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

With ammonium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1338349-27-1
tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 48 h / 20 °C / Cooling with ice

2: ammonium hydroxide; hydrogen / ethanol / 20 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

With ammonium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.030

Reference yield: 97.0%

: 1338349-27-1
tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

: 144-62-7,97993-78-7
oxalic acid

: 1338349-59-9
N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

Guidance literature:: tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 18h; Cooling with ice;

oxalic acid;
DOI:10.1016/j.bmc.2011.07.030