Technology Process of C17H20FN3O2
There total 4 articles about C17H20FN3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-iodo-1-(3-fluorophenyl)-1H-pyrazol-4-yl-carbamic acid 1,1-dimethylethyl ester; cyclopropylboronic acid;
With
potassium phosphate; palladium diacetate; tricyclohexylphosphine;
In
water; toluene;
at 100 - 110 ℃;
for 7h;
Inert atmosphere;
With
dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium diacetate;
In
water; toluene;
at 100 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran
2.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve
3.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere
3.2: 100 °C
With
potassium phosphate; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; palladium diacetate; triethylamine; tricyclohexylphosphine;
In
tetrahydrofuran; methanol; water; toluene;
3.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve
2.1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / toluene; water / 7 h / 100 - 110 °C / Inert atmosphere
2.2: 100 °C
With
potassium phosphate; diphenyl phosphoryl azide; palladium diacetate; triethylamine; tricyclohexylphosphine;
In
water; toluene;
2.1: |Suzuki Coupling;
