3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

• Chemical Name: 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
• CAS No.: 1533-17-1
• Molecular Formula: C₁₈H₁₂F₃NO₂
• Molecular Weight: 331.294
• Mol file: 1533-17-1.mol

Synonyms:3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property of 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 2 articles about 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(trifluoromethyl)propiophenone (1533-03-5) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (1533-17-1)

Guidance literature:

indole-2,3-dione; With potassium hydroxide; In ethanol; water; for 0.25h;

3-(trifluoromethyl)propiophenone; In ethanol; water; for 1h; Reflux;

With hydrogenchloride; In water; pH=3;

Reference yield:

→ 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (1533-17-1)

Guidance literature:

Isatin, KOH/A., m-Trifluormethyl-propiophenon;

DOI:10.1021/je60025a042

Reference yield:

methanol (67-56-1) + 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (1533-17-1) → methyl 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (1336964-34-1)

Guidance literature:

3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid; With thionyl chloride; for 2h; Reflux;

methanol; With triethylamine; for 0.166667h;

upstream raw materials:

3-(trifluoromethyl)propiophenone

indole-2,3-dione

Downstream raw materials:

methyl 3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

3-(1,4'-bipiperidin-1'-ylmethyl)-5-chloro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

3-(1,4'-bipiperidin-1'-ylmethyl)-5-chloro-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

methyl 3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate