5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline

Base Information

• Chemical Name: 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline
• CAS No.: 104598-57-4
• Molecular Formula: C₂₇H₂₅NO₄
• Molecular Weight: 427.5
• Mol file: 104598-57-4.mol

Synonyms:5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline

Chemical Property of 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline

There total 3 articles about 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

8-quinolinol (148-24-3,24804-14-6) + 3-(α-ethoxy-4-methoxybenzyl)-6-isopropyltropolone (92832-11-6) → 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline (104598-57-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; In xylene; for 5h; Heating;

DOI:10.1021/jm00384a020

Reference yield:

4-methoxybenzaldehyde diethylacetal (2403-58-9) → 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline (104598-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / toluene / 20 h / Heating

2: 29 percent / t-BuOK, hexamethylphosphoric triamide (HMPA) / xylene / 5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; In toluene; xylene;

DOI:10.1021/jm00384a020

Reference yield:

hinokitiol (499-44-5) → 5-<α-(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxybenzyl>-8-hydroxyquinoline (104598-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / toluene / 20 h / Heating

2: 29 percent / t-BuOK, hexamethylphosphoric triamide (HMPA) / xylene / 5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; In toluene; xylene;

DOI:10.1021/jm00384a020

upstream raw materials:

8-quinolinol

3-(α-ethoxy-4-methoxybenzyl)-6-isopropyltropolone

4-methoxybenzaldehyde diethylacetal

hinokitiol