6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine
• CAS No.: 662116-65-6
• Molecular Formula: C₁₈H₁₈Cl₂N₄O₂
• Molecular Weight: 393.273

Synonyms:6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine

Chemical Property of 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine

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Technology Process of 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine

There total 1 articles about 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(2-morpholin-4-yl-ethoxy)-benzoic acid (134599-45-4) + 2,3-diamino-4,5-dichloropyridine (662116-66-7) → 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (662116-65-6)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 10h;

Reference yield: 85.0%

1-indoline (496-15-1) + 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (662116-65-6) → 6-chloro-7-(2,3-dihydro-1H-indol-1-yl)-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridine (662116-82-7)

Guidance literature:

In xylene; at 180 ℃; for 0.333333h;

Reference yield: 80.0%

6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (662116-65-6) + benzylamine (100-46-9) → N-benzyl-6-chloro-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridin-7-amine

Guidance literature:

at 180 ℃; for 7h;

upstream raw materials:

4-(2-morpholin-4-yl-ethoxy)-benzoic acid

2,3-diamino-4,5-dichloropyridine

Downstream raw materials:

6-chloro-7-(4-methylphenyl)-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine

6-chloro-7-(4-morpholinyl)-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridine

6-chloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-7-pyrrolidin-1-yl-3H-imidazo[4,5-b]pyridin-7-amine

6-chloro-N-cyclopentyl-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridin-7-amine

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