662116-66-7

Basic information

• Product Name: 2,3-Diamino-4,5-dichloropyridine
• Synonyms: 2,3-Diamino-4,5-dichloropyridine
• CAS NO: 662116-66-7
• Molecular Formula: C₅H₅Cl₂N₃
• Molecular Weight: 178.0193
• Product Categories: Heterocycle-Pyridine series
• Mol File: 662116-66-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 344.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.602
• Storage Temp.: 2-8°C
• PKA: 3.52±0.50(Predicted)
• CAS DataBase Reference: 2,3-Diamino-4,5-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Diamino-4,5-dichloropyridine(662116-66-7)
• EPA Substance Registry System: 2,3-Diamino-4,5-dichloropyridine(662116-66-7)

Safety Data

• Hazardous Substances Data: 662116-66-7(Hazardous Substances Data)

Usage

General Description

2,3-Diamino-4,5-dichloropyridine is a chemical compound with the molecular formula C5H3Cl2N3. It is an aromatic heterocyclic compound that contains two amino groups and two chlorine atoms attached to a pyridine ring. 2,3-Diamino-4,5-dichloropyridine is used in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block in the production of various drugs and biologically active compounds. It is also used in the development of dyes, pigments, and other organic compounds. Additionally, 2,3-Diamino-4,5-dichloropyridine has been studied for its potential as a corrosion inhibitor in various industrial applications. However, it is important to handle this compound with caution, as it may have harmful effects on human health and the environment if not properly managed.

Upstream product

• 188577-68-6 4,5-dichloro-2-aminopyridine 
• 188577-71-1 N-(4,5-dichloropyridin-2-yl)-2,2-dimethylpropanamide 
• 188577-70-0 4-chloro-2-trimethylacetamidopyridine 
• 19798-80-2 2-Amino-4-chloropyridine 
• 662116-67-8 4,5-dichloro-3-nitropyridin-2-ylamine 

Downstream Products

• 662117-33-1 6,7-dichloro-2-[4-(4-morpholinyl)phenyl]-1H-imidazo[4,5-b]pyridine 
• 662116-65-6 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Identification of azabenzimidazoles as potent JAK1 selective inhibitors

We have identified a class of azabenzimidazoles as potent and selective JAK1 inhibitors. Investigations into the SAR are presented along with the structural features required to achieve selectivity for JAK1 versus other JAK family members. An example from

2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

A compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

A hit generation and exploration approach led to the discovery of 31 (2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide), a potent, novel inhibitor of Aurora-A, Aurora-B and Aurora-C kinases