(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

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Chemical Name:(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane
CAS No.:1367875-31-7
Molecular Formula:C₄₀H₃₇N₅O₃
Molecular Weight:635.765
Hs Code.:

Synonyms:(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

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Chemical Property of (1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

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Technology Process of (1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

There total 7 articles about (1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367874-84-7
3-(2-chloropyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 31560-06-2
(1S,4S)-(+)-2-Aza-5-oxabicyclo[2.2.1]heptane hydrochloride

: 1367875-31-7
(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: With potassium tert-butylate; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); ruphos; In 1,4-dioxane; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 134031-24-6
2,4-dichloro-3-pyridine Carboxaldehyde

: 1367875-31-7
(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

2.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 19 h / 20 °C

4.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 20 °C

4.2: 2 h / 190 °C / Microwave irradiation

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

6.1: potassium tert-butylate / chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); ruphos / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation

With potassium tert-butylate; iodine; potassium acetate; sodium hydride; hydrazine hydrate; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); ruphos; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1367875-31-7
(1S,4S)-5-(4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3.5 h / -78 - 0 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 19 h / 20 °C

5.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 20 °C

5.2: 2 h / 190 °C / Microwave irradiation

6.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

7.1: potassium tert-butylate / chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); ruphos / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation

With n-butyllithium; potassium tert-butylate; iodine; potassium acetate; sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); ruphos; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;