Chemical Property of Talmapimod
Chemical Property:
- Boiling Point:657.971 °C at 760 mmHg
- PKA:6.52±0.70(Predicted)
- Flash Point:351.729 °C
- PSA：65.86000
- Density:1.297 g/cm3
- LogP:3.85250
- Storage Temp.:Desiccate at +4°C
- XLogP3:3.7
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:512.1990467
- Heavy Atom Count:36
- Complexity:836
- Purity/Quality:
-
97% *data from raw suppliers
SCIO 469 hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F
- Isomeric SMILES:C[C@@H]1CN([C@H](CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F
- Recent ClinicalTrials:SCIO-469: Open-Label Study for Patients With Myelodysplastic Syndromes.
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Uses
Talmapimod is a p38 mitogen-activated protein (MAP) kinase inhibitor. Talmapimod reduced human myeloma cell growth in vivo both at early and advanced phases of the disease in mouse xenograft models. T
almapimod that blocks tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA) Talmapimod is a p38 mitogen-activated protein (MAP) kinase inhibitor. Talmapimod reduced human myeloma cell growth in vivo both at early and advanced phases of the disease in mouse xenograft models. Talmapimod that blocks tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA)
