Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Base Information

Chemical Name:Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide
CAS No.:500767-08-8
Molecular Formula:C₃₁H₃₄BrN₅O₅
Molecular Weight:636.545
Hs Code.:

Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Synonyms:Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

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Chemical Property of Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

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Technology Process of Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

There total 11 articles about Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-2-(4-Bromo-phenyl)-1-carbamoyl-ethyl]-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

: 500767-08-8
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: With caesium carbonate; In ethanol; at 20 ℃; for 1h;
DOI:10.1021/jm020951i

Reference yield:

: 98-98-6
2-Picolinic acid

: 500767-08-8
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

2: 43 mg / Cs₂CO₃ / ethanol / 1 h / 20 °C

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020951i

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 500767-08-8
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 9 steps

1: AcCl / 20 °C

2: 1.96 g / NH₃ / methanol

3: 62 percent / propan-2-ol / Heating

4: 99 percent / aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

5: HCl / ethyl acetate / 20 °C

6: 0.554 g / TBTU; DIEA / dimethylformamide / 20 °C

7: HCl / ethyl acetate / 0.25 h / 20 °C

8: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

9: 43 mg / Cs₂CO₃ / ethanol / 1 h / 20 °C

With hydrogenchloride; ammonia; sodium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i