(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

Base Information

Chemical Name:(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine
CAS No.:1434603-61-8
Molecular Formula:C₂₂H₂₂F₃NO
Molecular Weight:373.418
Hs Code.:

Synonyms:(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

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Chemical Property of (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

Chemical Property:

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Technology Process of (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

There total 7 articles about (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 3351-52-8
1-(3-bromopropoxy)-3-(trifluoromethyl)benzene

: 1434603-61-8
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

Guidance literature:: 1-(3-bromopropoxy)-3-(trifluoromethyl)benzene; With dmap; triethylamine; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

(R)-1-(1-Naphthyl)ethylamine; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo400371x

Reference yield:

: 98-17-9
3-Trifluoromethylphenol

: 1434603-61-8
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 25 °C

2.1: triethylamine; dmap / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

2.2: 0.5 h / 25 °C / Inert atmosphere

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo400371x

Reference yield:

: 941-98-0
1'-naphthacetophenone

: 1434603-61-8
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / dichloromethane / 1 h / 0 °C

2.1: hydroxylamine hydrochloride / water; methanol / 25 °C

3.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 18 h / 20 °C

5.1: C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / Inert atmosphere

6.1: triethylamine; dmap / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

6.2: 0.5 h / 25 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; borane-THF; C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; hydroxylamine hydrochloride; bromine; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo400371x