(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

Base Information

Chemical Name:(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt
CAS No.:1434603-64-1
Molecular Formula:C₂₂H₂₂F₃NO*ClH
Molecular Weight:409.879
Hs Code.:

Synonyms:(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

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Chemical Property of (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

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Technology Process of (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

There total 7 articles about (R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1434603-61-8
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine

: 1434603-64-1
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

Guidance literature:: With methanol; chloro-trimethyl-silane; In dichloromethane; at 25 ℃;
DOI:10.1021/jo400371x

Reference yield:

: 941-98-0
1'-naphthacetophenone

: 1434603-64-1
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / dichloromethane / 1 h / 0 °C

2.1: hydroxylamine hydrochloride / water; methanol / 25 °C

3.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 18 h / 20 °C

5.1: C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / Inert atmosphere

6.1: triethylamine; dmap / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

6.2: 0.5 h / 25 °C / Inert atmosphere

7.1: chloro-trimethyl-silane; methanol / dichloromethane / 25 °C

With methanol; dmap; sodium tetrahydroborate; chloro-trimethyl-silane; borane-THF; C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; hydroxylamine hydrochloride; bromine; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo400371x

Reference yield:

: 98-17-9
3-Trifluoromethylphenol

: 1434603-64-1
(R)-N-1-(naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propan]-1-amine hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 25 °C

2.1: triethylamine; dmap / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

2.2: 0.5 h / 25 °C / Inert atmosphere

3.1: chloro-trimethyl-silane; methanol / dichloromethane / 25 °C

With methanol; dmap; chloro-trimethyl-silane; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo400371x