4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Base Information

Chemical Name:4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
CAS No.:327036-89-5
Molecular Formula:C₁₀H₁₀N₂O₂S
Molecular Weight:222.268
Hs Code.:2934999090
European Community (EC) Number:636-505-3
DSSTox Substance ID:DTXSID30399590
Nikkaji Number:J1.720.195F
Wikidata:Q27077898
Pharos Ligand ID:HYJY6Z1R8SWA
ChEMBL ID:CHEMBL284861
Mol file:327036-89-5.mol

Synonyms:4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione;TDZD-8;thiadiazolidinone-8

Suppliers and Price of 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC)
25mg
$ 351.00

TCI Chemical
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC)
5mg
$ 118.00

Sigma-Aldrich
TDZD-8 ≥98% (HPLC), needles
5mg
$ 145.00

Sigma-Aldrich
GSK-3β Inhibitor I
5mg
$ 109.15

Sigma-Aldrich
TDZD-8 ≥98% (HPLC), needles
25mg
$ 522.00

DC Chemicals
TDZD-8 >98%
250 mg
$ 700.00

DC Chemicals
TDZD-8 >98%
100 mg
$ 400.00

CSNpharm
TDZD-8
1mg
$ 30.00

CSNpharm
TDZD-8
5mg
$ 45.00

CSNpharm
TDZD-8
10mg
$ 54.00

Total 60 raw suppliers

Chemical Property of 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Chemical Property:

Appearance/Colour:White Solid
Vapor Pressure:0.000119mmHg at 25°C
Melting Point:63-64.4 °C
Refractive Index:1.645
Boiling Point:335.5 °C at 760 mmHg
PKA:-2.08±0.20(Predicted)
Flash Point:156.7 °C
PSA：72.24000
Density:1.375 g/cm³
LogP:0.65680
Storage Temp.:2-8°C
Solubility.:DMSO: 18 mg/mL
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:222.04629874
Heavy Atom Count:15
Complexity:277

Purity/Quality:

99%, ^*data from raw suppliers

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2
Uses Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Technology Process of 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

There total 2 articles about 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55000-02-7
N-benzyl-S-chloroisothiocarbamoyl chloride

: 327036-89-5
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hexane / 12 h / 20 °C

2: ethanol / 12 h / 20 °C

In ethanol; hexane;
DOI:10.1016/S0223-5234(00)01166-1