(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

Base Information

Chemical Name:(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine
CAS No.:153181-20-5
Molecular Formula:C₃₀H₅₂N₂O₄Si₂
Molecular Weight:560.925
Hs Code.:

Synonyms:(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

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Chemical Property of (2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

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Technology Process of (2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

There total 8 articles about (2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 153181-18-1
dibenzyl ((2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diyl)dicarbamate

: 153181-20-5
(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h;
DOI:10.1021/jm970524i

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 153181-20-5
(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 3 h / Ambient temperature

3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C

4: VCl₃(THF)3, Zn-Cu / CH₂Cl₂ / 3 h / Ambient temperature

5: N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature

6: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating

With 4-methyl-morpholine; lithium aluminium tetrahydride; Vanadium (III) chloride-(tris-tetrahydrofuran); copper; N-ethyl-N,N-diisopropylamine; zinc; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n

Reference yield:

: 153223-10-0
(2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol

: 153181-20-5
(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / diisopropylethylamine / dimethylformamide / 16 h / Ambient temperature

2: 99 percent / H₂ / 5percent Pd/C / ethanol / 1.5 h

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970524i