(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

Base Information

Chemical Name:(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one
CAS No.:153181-22-7
Molecular Formula:C₃₁H₅₀N₂O₅Si₂
Molecular Weight:586.919
Hs Code.:

Synonyms:(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

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Technology Process of (4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

There total 11 articles about (4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 201230-82-2
carbon monoxide

: 153181-20-5
(2R,3S,4S,5R)-1,6-diphenyl-3,4-bis((2-(trimethylsilyl)ethoxy)methoxy)hexane-2,5-diamine

: 153181-22-7
(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

Guidance literature:: With iodine; potassium carbonate; tungsten hexacarbonyl; In dichloromethane; water; at 82 ℃; under 58523.9 Torr;
DOI:10.1021/jo026816v

Reference yield: 52.0%

: (4R,5S,6S,7R)-4,7-Dibenzyl-2-oxo-5,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-[1,3]diazepane-1,3-dicarboxylic acid dibenzyl ester

: 153181-22-7
(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/jm9602571

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 153181-22-7
(4R,5S,6S,7R)-hexahydro-5,6-bis[2-(trimethylsilyl)ethoxymethoxy]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 3 h / Ambient temperature

3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C

4: VCl₃(THF)3, Zn-Cu / CH₂Cl₂ / 3 h / Ambient temperature

5: N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature

6: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating

7: CH₂Cl₂ / 18 h / Heating

With 4-methyl-morpholine; lithium aluminium tetrahydride; Vanadium (III) chloride-(tris-tetrahydrofuran); copper; N-ethyl-N,N-diisopropylamine; zinc; cyclohexene; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960083n