1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

Base Information

• Chemical Name: 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one
• CAS No.: 1284258-80-5
• Molecular Formula: C₁₇H₂₀Cl₂N₄O₃
• Molecular Weight: 399.277
• Mol file: 1284258-80-5.mol

Synonyms:1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

Chemical Property of 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one

There total 2 articles about 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethacrynic acid (58-54-8) + 4-azidobutan-1-amine (88192-20-5) → 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-80-5)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.01.068

Reference yield: 86.0%

→ 1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-80-5)

Guidance literature:

Reference yield: 80.0%

1-{4-[(4-azidobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-80-5) → 1-{4-[(4-aminobutylaminooxy)methyl]-2,3-dichlorophenyl}-2-methylenebutan-1-one (1284258-81-6)

Guidance literature:

With 10% palladium on activated charcoal; hydrogen; In methanol; for 0.833333h;

DOI:10.1016/j.bmcl.2011.01.068

upstream raw materials:

ethacrynic acid

4-azidobutan-1-amine

Downstream raw materials:

C₃₄H₄₄Cl₂N₂O₅

C₃₁H₃₇Cl₂N₇O₅

C₂₄H₂₆Cl₃N₃O₄

C₂₅H₂₇Cl₃N₂O₄S