4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate
• CAS No.: 1025468-89-6
• Molecular Formula: C₂₅H₂₀F₄INO₅S
• Molecular Weight: 649.402

Synonyms:4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

Chemical Property of 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

There total 2 articles about 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-(4-iodophenyl)azetidin-2-one (1025468-48-7) → 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate (1025468-89-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-(4-iodophenyl)azetidin-2-one (1025468-48-7) → 4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate (1025468-89-6)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

Reference yield:

4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate (1025468-89-6) + acetic anhydride (108-24-7) → (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate (1025468-50-1)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

trifluoromethylsulfonic anhydride

(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-(4-iodophenyl)azetidin-2-one

N,N-phenylbistrifluoromethane-sulfonimide

Downstream raw materials:

(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

4-[(2S,3R)-3-[3-(4-fluorophenyl)-3-oxopropyl]-2-(4-iodophenyl)-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

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