(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

Base Information

• Chemical Name: (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate
• CAS No.: 1025468-50-1
• Molecular Formula: C₂₇H₂₂F₄INO₆S
• Molecular Weight: 691.439

Synonyms:(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

Chemical Property of (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

Chemical Property:

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MSDS Files:

Useful:

Technology Process of (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate

There total 3 articles about (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate (1025468-89-6) + acetic anhydride (108-24-7) → (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate (1025468-50-1)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-hydroxyphenyl)-2-(4-iodophenyl)-2-(4-iodophenyl)-4-oxoazetidin-3-yl]propyl acetate (1025468-51-2) → (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate (1025468-50-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-hydroxyphenyl)-2-(4-iodophenyl)-2-(4-iodophenyl)-4-oxoazetidin-3-yl]propyl acetate (1025468-51-2) → (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate (1025468-50-1)

Guidance literature:

With pyridine; In dichloromethane; for 1.33333h;

upstream raw materials:

trifluoromethylsulfonic anhydride

(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-hydroxyphenyl)-2-(4-iodophenyl)-2-(4-iodophenyl)-4-oxoazetidin-3-yl]propyl acetate

4-[(2S,3R)-3-[3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-iodophenyl)]-4-oxoazetidin-1-yl]phenyl trifluoromethanesulfonate

acetic anhydride

Downstream raw materials:

(1S)-3-[(2S,3R)-2-(4-allylphenyl)-4-oxo-1-(4{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]-1-(4-fluorophenyl)propyl acetate

(1S)-3-[(2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}-phenyl)azetidin-3-yl]-1-(4-fluorophenyl)propyl acetate

(1S)-3-[(2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}-phenyl)azetidin-3-yl]-1-(4-fluorophenyl)propyl acetate

dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

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