(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

Base Information

Chemical Name:(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol
CAS No.:1432051-32-5
Molecular Formula:C₁₉H₂₀F₃N₃O₂
Molecular Weight:379.382
Hs Code.:

Synonyms:(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

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Chemical Property of (S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

Chemical Property:

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Technology Process of (S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

There total 10 articles about (S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432048-90-2
(S)-3-[hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethoxy)phenyl]-cyclobutanone

: 57-14-7
N,N-Dimethylhydrazine

: 1432051-32-5
(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

Guidance literature:: With acetic acid; In tetrahydrofuran; at 20 - 60 ℃; for 3h;

Reference yield:

: 49561-96-8
(4-trifluoromethoxy-phenyl)-acetonitrile

: 1432051-32-5
(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / dimethyl sulfoxide; water / 20 - 125 °C

2.1: methanol / 20 - 70 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.67 h / -78 °C

3.2: -78 - 20 °C

4.1: formic acid; triethylamine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / 192 h / 55 °C

5.1: acetic acid / tetrahydrofuran / 3 h / 20 - 60 °C

With methanol; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); n-butyllithium; formic acid; acetic acid; triethylamine; sodium t-butanolate; In tetrahydrofuran; diethyl ether; hexane; water; dimethyl sulfoxide;

Reference yield:

: 1432048-71-9
3-hydroxy-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

: 1432051-32-5
(S)-{3-(dimethylhydrazinylidene)-1-[4-(trifluoromethoxy)phenyl]-cyclobutyl}(pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux

1.2: 20 - 100 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.75 h / Cooling with acetone-dry ice

2.2: 20 °C

3.1: methanol; sodium tetrahydroborate / 20 °C

4.1: hydrogenchloride / water; acetone / 20 °C

5.1: Chiralpak AD DAC column / Resolution of racemate

6.1: acetic acid / tetrahydrofuran / 3 h / 20 - 60 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; diethyl ether; hexane; water; acetone; toluene;