3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate

Base Information

• Chemical Name: 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate
• CAS No.: 1163693-69-3
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 1163693-69-3.mol

Synonyms:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate

Chemical Property of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate

There total 2 articles about 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C16H22O4 (1163693-76-2) → 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate (1163693-69-3)

Guidance literature:

With water; toluene-4-sulfonic acid; In methanol;

DOI:10.1021/ol900828x DOI:10.1016/j.tet.2009.09.111

Reference yield: 70.0%

2-methyl-3-(4-methylbenzoyloxy)-2-((4-(trifluoromethyl)benzoyloxy)methyl)propyl 3,5-bis(trifluoromethyl)benzoate (1163693-67-1) → 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate (1163693-69-3)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol; at 90 ℃; chemoselective reaction; Electrochemical reaction;

DOI:10.1021/ol900828x

Reference yield: 80.0%

3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 4-methylbenzoate (1163693-69-3) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → 3-hydroxy-2-methyl-2-((4-(trifluoromethyl)benzoyloxy)methyl)propyl 4-methylbenzoate (1163693-71-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/ol900828x

upstream raw materials:

2-methyl-3-(4-methylbenzoyloxy)-2-((4-(trifluoromethyl)benzoyloxy)methyl)propyl 3,5-bis(trifluoromethyl)benzoate

C₁₆H₂₂O₄

Downstream raw materials:

3-hydroxy-2-methyl-2-((4-(trifluoromethyl)benzoyloxy)methyl)propyl 4-methylbenzoate