(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

Base Information

Chemical Name:(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone
CAS No.:1430738-37-6
Molecular Formula:C₃₄H₅₃FN₂O₄Si₂
Molecular Weight:628.975
Hs Code.:

(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

Synonyms:(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

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Chemical Property of (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

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Technology Process of (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

There total 8 articles about (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1430738-36-5
(S)-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)(5-methoxy-2-nitro-4-((trisopropylsilyl)oxy)phenyl)methanone

: 1430738-37-6
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: With formic acid; zinc; In ethanol; at 15 - 30 ℃; for 0.5h;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-37-6
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

3: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

With 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; zinc; In 1,4-dioxane; ethanol; dichloromethane; 2: |Suzuki Coupling;

Reference yield:

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

: 1430738-37-6
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl)(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-fluorophenyl)-2,3-dihydro-1H-pyrrol-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.33 h / 0 - 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

4: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

With 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; zinc; In 1,4-dioxane; ethanol; dichloromethane; 3: |Suzuki Coupling;