(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Base Information

Chemical Name:(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate
CAS No.:1430738-40-1
Molecular Formula:C₃₂H₄₁FN₂O₆Si
Molecular Weight:596.771
Hs Code.:

(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Synonyms:(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Chemical Property of (11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Technology Process of (11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

There total 11 articles about (11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1430738-39-8
(S)-allyl (2-(4-(4-fluorophenyl)-2-(hydroxymethyl)-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

: 1430738-40-1
(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: (S)-allyl (2-(4-(4-fluorophenyl)-2-(hydroxymethyl)-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-40-1
(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

3.1: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

4.1: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

5.1: acetic acid / methanol; water; tetrahydrofuran-d8 / 3 h / 20 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; oxalyl dichloride; acetic acid; dimethyl sulfoxide; zinc; In 1,4-dioxane; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; water; 2.1: |Suzuki Coupling;

Reference yield:

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

: 1430738-40-1
(11S,11aS)-allyl 2-(4-fluorophenyl)-11-hydroxy-7-methoxy-5-oxo-8-((triisopropylsilyl)oxy)-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.33 h / 0 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

4.1: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

5.1: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

6.1: acetic acid / methanol; water; tetrahydrofuran-d8 / 3 h / 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

7.2: -78 - 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; acetic acid; dimethyl sulfoxide; zinc; In 1,4-dioxane; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; water; 3.1: |Suzuki Coupling;