Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

Base Information

• Chemical Name: Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate
• CAS No.: 91476-82-3
• Molecular Formula: C9H13N3O2
• Molecular Weight: 195.22
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID40977949
• Wikidata: Q72477304
• Mol file: 91476-82-3.mol

Synonyms:Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate;91476-82-3;ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2-carboxylate;5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester;MFCD08059257;SCHEMBL929672;DTXSID40977949;YTYJZXFCWYHVPG-UHFFFAOYSA-N;AMY20500;SC2741;AKOS006284462;AB43052;SY008395;TS-00300;CS-0041590;FT-0693333;EN300-153999;A833753;A860363;J-521078;Ethyl5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate;Ethyl 5 pound not6 pound not7 pound not8-Tetrahydroimidazo[1 pound not2-a]pyrazine-2-carboxylate;ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate;Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride

Chemical Property of Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

Chemical Property:

• Boiling Point: 394.02 °C at 760 mmHg
• Flash Point: 192.097 °C
• PSA: 56.15000
• Density: 1.36 g/cm³
• LogP: 0.49180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 195.100776666
• Heavy Atom Count: 14
• Complexity: 222

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2CCNCC2=N1

Technology Process of Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

There total 4 articles about Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle (91476-82-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; water; Flow reactor; Heating;

DOI:10.1002/ejoc.201801684

Reference yield: 83.0%

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate (1053656-22-6) → tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle (91476-82-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

ethyl Bromopyruvate (70-23-5) → tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle (91476-82-3)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂ / PtO₂ / ethanol / 1 h

With hydrogen; platinum(IV) oxide; In ethanol;

upstream raw materials:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

ethyl Bromopyruvate

ethyl 3-bromo-2-hydroxy propionate

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

Downstream raw materials:

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

ethyl 7-[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

ethyl 7-(o-tolylcarbamoyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate

ethyl 7-(1-methylcyclohexanecarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate