4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl

Base Information

• Chemical Name: 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl
• CAS No.: 832735-41-8
• Molecular Formula: C14H20BrN3O3
• Molecular Weight: 358.235
• Hs Code.: 2933990090
• Mol file: 832735-41-8.mol

Synonyms:tert-Butyl 4-[(5-bromopyrimidin-2-yl)oxy]piperidine-1-carboxylate;1-Boc-4-(5-bromopyrimidin-2-yloxy)piperidine;4-(5-Bromopyrimidin-2-Yloxy)Piperidine-1-Carboxylicacidtert-Butyl ester;4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl;

Chemical Property of 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl

Chemical Property:

• Vapor Pressure: 2.4E-08mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 451.6 °C at 760 mmHg
• Flash Point: 226.9 °C
• PSA: 64.55000
• Density: 1.394 g/cm³
• LogP: 2.95530
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl

There total 2 articles about 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-Bromo-2-chloropyrimidine (32779-36-5) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((5-bromopyrimidin-2-yl)oxy)piperidine-1-carboxylate (832735-41-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield: 44.0%

→ tert-butyl 4-((5-bromopyrimidin-2-yl)oxy)piperidine-1-carboxylate (832735-41-8)

Guidance literature:

Reference yield: 79.0%

tert-butyl 4-((5-bromopyrimidin-2-yl)oxy)piperidine-1-carboxylate (832735-41-8) + phenylboronic acid (98-80-6) → t-butyl 4-[(5-phenylpyrimidin-2-yl)oxy]piperidine-1-carboxylate (1189551-44-7)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; Inert atmosphere; Reflux;

upstream raw materials:

5-Bromo-2-chloropyrimidine

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

2-(1-tert-butoxycarbonylpiperidine-4-yloxy)-5-(4-cyanophenyl)pyrimidine

t-butyl 4-[(5-pyridin-2-ylpyrimidin-2-yl)oxy]piperidine-1-carboxylate

t-butyl 4-[(5-phenylpyrimidin-2-yl)oxy]piperidine-1-carboxylate

Refernces

• 1、 -. "HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE". Page/Page column 104. . Retrieved 2010/12/29.
• 2、 -. "TREATMENT OF STROKE WITH HISTAMINE H3 INVERSE AGONISTS OR HISTAMINE H3 ANTAGONISTS". Page/Page column 8. . Retrieved 2008/06/13.