5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID
• CAS No.: 1975-44-6
• Molecular Formula: C11H7NO4
• Molecular Weight: 217.181
• Hs Code.: 2916399090
• Mol file: 1975-44-6.mol

Synonyms:1-Naphthoicacid, 5-nitro- (6CI,7CI,8CI);5-Nitro-1-naphthalenecarboxylic acid;5-Nitro-1-naphthoic acid;

Chemical Property of 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 7.4E-09mmHg at 25°C
• Melting Point: 241.5°C
• Refractive Index: 1.706
• Boiling Point: 449.3 °C at 760 mmHg
• PKA: 2.61±0.10(Predicted)
• Flash Point: 199.2 °C
• PSA: 83.12000
• Density: 1.468 g/cm³
• LogP: 2.96940
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Nitro-1-naphthoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID

There total 21 articles about 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-naphthalenecarboxylic acid (86-55-5) → 5-nitro-1-naphthoic acid (1975-44-6) + 8-nitro-1-naphthalenecarboxylic acid (2216-13-9)

Guidance literature:

With nitric acid; for 4h;

DOI:10.1248/cpb.32.3968

Reference yield:

1-naphthalenecarboxylic acid (86-55-5) → 5-nitro-1-naphthoic acid (1975-44-6)

Guidance literature:

With nitric acid; acetic acid; Isolierung aus dem Reaktionsprodukts ueber den Methylester;

DOI:10.1021/ja01874a054

Reference yield:

4-nitronaphthalic-1,8-anhydride (6642-29-1) → 4-nitro-1-naphthoic acid (1975-43-5) + 5-nitro-1-naphthoic acid (1975-44-6)

Guidance literature:

4-nitronaphthalic-1,8-anhydride; With sodium hydroxide; In water; at 100 ℃; for 0.0166667h; microwave irradiation;

With mercury(II) diacetate; In water; at 200 ℃; for 0.5h; microwave irradiation;

With hydrogenchloride; In water; at 120 ℃; for 0.25h; Title compound not separated from byproducts; microwave irradiation;

DOI:10.1016/j.tet.2005.12.064

upstream raw materials:

1-naphthalenecarboxylic acid

8-chloro-5-nitro-[1]naphthoic acid

5-nitro-1-hydroxymethylnaphthalene

8-bromo-5-nitro-naphthalene-1-carboxylic acid

Downstream raw materials:

ethyl 5-nitro-1-naphthoate

(S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid

(S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester

(S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid

Refernces

• 1、 Moseley, Jonathan D.,Gilday, John P.. "The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis". . p. 4690 - 4697. Retrieved 2007/10/03.
• 2、 Weinstock,Rost,Cheng. "Synthesis of new polyamine derivatives for cancer chemotherapeutic studies". . p. 956 - 959. Retrieved 2007/10/02.