5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

Base Information

Chemical Name:5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine
CAS No.:1039052-95-3
Molecular Formula:C₂₆H₃₇N₄O₉P
Molecular Weight:580.575
Hs Code.:

Synonyms:5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

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Chemical Property of 5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

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Technology Process of 5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

There total 3 articles about 5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879494-66-3
2′-C-methyl-2′,3′-O-isopropylidencytidine

: 25632-56-8
2-(pivaloyloxy)ethan-1-aminium chloride

: 4712-55-4
diphenyl hydrogen phosphite

: 1039052-95-3
5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

Guidance literature:: 2′-C-methyl-2′,3′-O-isopropylidencytidine; diphenyl hydrogen phosphite; In pyridine; at 0 ℃; for 1h; Molecular sieve;

2-(pivaloyloxy)ethan-1-aminium chloride; With hexachloroethane; triethylamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 25632-56-8
2-(pivaloyloxy)ethan-1-aminium chloride

: 1085446-51-0
[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

: 1039052-95-3
5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

Guidance literature:: With triethylamine; In tetrahydrofuran; tetrachloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2009.01.035

Reference yield:

: 20724-73-6,115494-60-5
2'-C-methylcytidine

: 1039052-95-3
5'-O-[[[2-(2,2-dimethyl-1-oxopropoxy)-ethyl]-amino]-phenoxyphosphinyl]-2'-C-methyl-2',3'-O-(1-methylethylidene)-cytidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / acetone / 24 h / 20 °C

1.2: 2 h

2.1: pyridine / 1 h / 0 °C / Molecular sieve

2.2: 0.5 h / 0 °C

With toluene-4-sulfonic acid; In pyridine; acetone;