[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

Base Information

Chemical Name:[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate
CAS No.:1085446-51-0
Molecular Formula:C₁₉H₂₄N₃O₇P
Molecular Weight:437.389
Hs Code.:

Synonyms:[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

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Chemical Property of [(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

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Technology Process of [(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

There total 1 articles about [(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 879494-66-3
2′-C-methyl-2′,3′-O-isopropylidencytidine

: 4712-55-4
diphenyl hydrogen phosphite

: 1085446-51-0
[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

Guidance literature:: With pyridine; at 0 ℃; for 1h; Molecular sieve;
DOI:10.1016/j.bmcl.2009.01.035

Reference yield:

: 1085446-51-0
[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

: 1085446-50-9
(1S)-1-[3-(1-propylbutyl)-1,2,4-oxadiazol-5-yl]ethanaminium chloride

: 1085446-52-1
((3aR,4R,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl phenyl ((S)-1-(3-(1-propylbut-1-yl)-1,2,4-oxadiazol-5-yl)ethyl)phosphoramidate

Guidance literature:: (1S)-1-[3-(1-propylbutyl)-1,2,4-oxadiazol-5-yl]ethanaminium chloride; With tetrachloromethane; triethylamine; In isopropyl alcohol; acetonitrile;

[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 1085446-37-2
2-aminoethyl 2-propylpentanoate hydrochloride

: 1085446-51-0
[(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate

: 1142811-48-0
C₂₉H₄₃N₄O₉P

Guidance literature:: With triethylamine; In tetrahydrofuran; tetrachloromethane; isopropyl alcohol; at 0 ℃; for 0.5h; Large scale reaction;
DOI:10.1016/j.bmcl.2009.01.035