5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

Base Information

Chemical Name:5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid
CAS No.:405196-11-4
Molecular Formula:C₁₆H₂₃FNO₆P
Molecular Weight:375.334
Hs Code.:

Synonyms:5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

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Chemical Property of 5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

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Technology Process of 5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

There total 6 articles about 5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 405196-10-3
5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid benzyl ester

: 405196-11-4
5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h;
DOI:10.1016/S0968-0896(01)00231-0

Reference yield:

: 1198-84-1
4-hydroxymandelic acid

: 405196-11-4
5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / 1-hydroxybenzotriazole mohohydrate; diisopropylethylamine; (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

2: 55 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / 20 °C

3: 70 percent / diethylamino sulfur trifluoride / CH₂Cl₂ / 1 h / 0 °C

4: 99 percent / hydrogen / Pd/C / ethanol / 1 h

With diethylamino-sulfur trifluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00231-0

Reference yield:

: 627-95-2
5-amino-valeric acid ; hydrochloride

: 405196-11-4
5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / 4-toluenesulfonic acid monohydrate / Heating

2: 72 percent / 1-hydroxybenzotriazole mohohydrate; diisopropylethylamine; (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 24 h / 20 °C

3: 55 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / 20 °C

4: 70 percent / diethylamino sulfur trifluoride / CH₂Cl₂ / 1 h / 0 °C

5: 99 percent / hydrogen / Pd/C / ethanol / 1 h

With diethylamino-sulfur trifluoride; p-toluenesulfonic acid monohydrate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00231-0