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Usage

Uses

Used in Pharmaceutical Industry:
5-Aminovaleric Acid Hydrochloride is used as a synthetic precursor for the production of antibiotics, specifically antibiotics XIV. It plays a vital role in the development of new antibiotics to combat bacterial infections and contribute to the ongoing fight against antibiotic resistance.
Used in Research and Development:
5-AMINOVALERIC ACID HYDROCHLORIDE is also utilized as a reagent in the study of the reaction between thiolactams and ethyl chloroacetate. Understanding these reactions can lead to the discovery of new chemical pathways and the development of novel pharmaceutical compounds.
Used in the Synthesis of Hydroxymethyl Dihydroisoxazole Derivatives:
5-Aminovaleric Acid Hydrochloride is employed as a key component in the synthesis of hydroxymethyl dihydroisoxazole derivatives. These derivatives have potential applications as antibiotic agents, further expanding the utility of 5-AMINOVALERIC ACID HYDROCHLORIDE in the pharmaceutical sector.

Purification Methods

Crystallise the salt from CHCl3. Otherwise dissolve it in EtOH and add 2 volumes of Et2O and chill. [Schniepp & Marvel J Am Chem Soc 57 1557 1935, Woods & Colver J Am Chem Soc 67 654 1945, Beilstein 4 III 1343, 4 IV 2636.]

InChI:InChI=1/C5H11NO2.ClH/c6-4-2-1-3-5(7)8;/h1-4,6H2,(H,7,8);1H

Upstream product

• 675-20-7 piperidin-2-one 
• 70320-18-2 5-(Methoxycarbonylamino)valeriansaeure-methylester 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 7647-01-0 hydrogenchloride 
• 27219-07-4 5-(N-tert-butyloxycarbonyl)aminopentanoic acid 
• 142-08-5 2-Pyridone 
• 660-88-8 5-aminopentanoic acid 
• 138286-84-7 Methyl N-(trichloroacetyl)-5-aminopentanoate 

Downstream Products

• 5100-16-3 5-(3-Phenyl-ureido)-valeriansaeure-anilid 
• 15764-83-7 N^α-carbobenzoxy-N^G-tosyl-Arg-δ-amino-valeriansaeuremethylester 
• 15889-52-8 N^α-Carbobenzoxy-N^G-tosyl-Arg-N^G-tosyl-Arg-δ-amino-valeriansaeuremethylester 
• 23135-50-4 5-(N-benzyloxycarbonylamino)pentanoic acid 
• 1073697-07-0 5-(2,4,6-Trichloro-phenylsulfonamido)pentanoic acid 
• 29840-56-0 5-aminopentanoic acid methyl ester hydrochloride 
• 340962-84-7 1-(1-benzylpiperidin-4-yl)-piperidin-2-one 
• 405196-22-7 5-(3-{4-[(3-acetyl-phenoxy)-ethyl-phosphinoyloxy]-phenyl}-3-hydroxy-propionylamino)-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 405196-20-5 5-(3-{4-[(3-acetyl-phenoxy)-ethyl-phosphinoyloxy]-phenyl}-3-hydroxy-propionylamino)-pentanoic acid benzyl ester 
• 405196-21-6 5-(3-{4-[(3-acetyl-phenoxy)ethyl-phosphinoyloxy]phenyl}-3-hydroxy-propionylamino)pentanoic acid 
• 405196-10-3 5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid benzyl ester 
• 405196-09-0 5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-hydroxy-acetylamino}pentanoic acid benzyl ester 

Relevant academic research and scientific papers

An Efficient Two-Step Preparation of α-, β-, γ- or δ-Amino Acids from 2-Pyrazinones, 2-Hydroxypyrimidines or 2-Pyridones Respectively

A practical and efficient two-step procedure is reported for the preparation of a variety of α-, β-, γ- and δ-amino acids from 2-pyridone, 2-pyrazinone or 2-hydroxypyrimidine and derivatives. The procedure is amenable to scale-up and in most cases no chromatographic purification of the product is required. This approach is useful, especially in the synthesis of amino acids or deuterated amino acids that are not obtained by other methods.

An Efficient Route to N-Monosubstituted Guanidino-Lactams

A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation

Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.

Aminosaeuren, I. Darstellung von Aminosaeuren aus Halogencarbonsaeure-alkylestern mit Alkalimetallcyanaten

α- and ω-halo- as well as α,ω-dihalocarboxylic alkyl esters react with potassium cyanate in the presence of alcohol at 80 - 120 deg C in dipolar aprotic solvents to yield α- and ω-(alkoxycarbonylamino)- and α,ω-bis(alkoxycarbonylamino)carboxylic alkyl esters, respectively, in good yields.Hydrolytic cleavage of these mono- or diurethanes with an aqueous solution of hydrochloric acid/formic acid leads to the corresponding amino acid hydrochlorides in nearly quantitative yields.