6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one
CAS No.:1452231-20-7
Molecular Formula:C₂₆H₂₃Cl₂N₅O₂
Molecular Weight:508.407
Hs Code.:

Synonyms:6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

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Chemical Property of 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

There total 10 articles about 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092794-11-0
2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-amine

: 1452230-82-8
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

: 1452231-20-7
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.5h;

2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-amine; With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 3h;

Reference yield:

: 1092794-11-0
2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-amine

: C₁₅H₁₁Cl₂N₃O₄S

: 1452231-20-7
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: With trifluoroacetic acid; at 50 ℃; for 3h;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 1452230-53-3
6-(2,6-dichlorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

: 1452231-20-7
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.17 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

2.2: 3 h / 50 °C

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;