1452230-53-3

Upstream product

• 1452230-66-8 N-(2,6-dichlorophenyl)-4-ethyl-2-(methylthio)pyrimidine-5-carboxamide 
• 3724-43-4 Vilsmeier reagent 
• 68-12-2 N,N-dimethyl-formamide 
• 188937-15-7 4-ethyl-2-methylsulfanyl-pyrimidine-5-carbonyl chloride 
• 188937-14-6 4-ethyl-2-(methylthio)pyrimidine-5-carboxylic acid 
• 1452230-52-2 N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide 
• 98276-75-6 4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid 
• 7234-25-5 4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1452230-57-7 8-(1,3-benzothiazol-2-yl)-6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-59-9 8-(1H-benzimidazol-2-yl)-6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-84-0 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-54-4 6-(2,6-dichlorophenyl)-2-(methylthio)-8-((phenylamino)methyl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452231-63-8 tert-butyl 6-(6-(2,6-dichlorophenyl)-8-formyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1452230-64-6 6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde 
• 1452230-80-6 6-(2,6-dichlorophenyl)-8-(difluoromethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452231-11-6 2-amino-6-(2,6-dichlorophenyl)-8-(1H-imidazol-2-yl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-62-4 6-(2,6-dichlorophenyl)-2-(methylthio)-8-vinylpyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-60-2 8-(1H-benzo[d]imidazol-2-yl)-6-(2,6-dichlorophenyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-58-8 8-(benzo[d]thiazol-2-yl)-6-(2,6-dichlorophenyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-56-6 6-(2,6-dichlorophenyl)-2-(methylthio)-8-((2,2,2-trifluoroethylamino)methyl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452232-82-4 6-(2,6-dichlorophenyl)-8-(1-hydroxyethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452231-64-9 tert-butyl 6-(6-(2,6-dichlorophenyl)-8-(1H-imidazol-2-yl)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant academic research and scientific papers

Investigation of biaryl heterocycles as inhibitors of Wee1 kinase

In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ

PYRIDOPYRIMIDINONE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions cont