methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

Base Information

Chemical Name:methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate
CAS No.:207224-12-2
Molecular Formula:C₄₆H₅₂O₇Si
Molecular Weight:745
Hs Code.:

Synonyms:methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

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Chemical Property of methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

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Technology Process of methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

There total 6 articles about methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: C₄₄H₄₈O₇Si

: 207224-12-2
methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

Guidance literature:: In diethyl ether;
DOI:10.1002/hlca.19980810313

Reference yield:

: 6232-88-8
4-bromomethylbenzoic Acid

: 207224-12-2
methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, reflux, 30 min, 2) THF, RT, 24 h then reflux, 1 h and overnight, RT

2: 63 percent / diethyl ether

With sodium hydride; In diethyl ether;
DOI:10.1002/hlca.19980810313

Reference yield:

: 146952-73-0
[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl]methanol

: 207224-12-2
methyl 4-({[(1R,2S)-2-(4-{[(tert-butyl)diphenylsilyloxy]methyl}benzyl)-3-4-(methoxycarbonyl)benzyloxy]-1-methylpropyloxy}methyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: Ph₃P, Br₂ / tetrahydrofuran / 13 h / Ambient temperature

2: 1) BuLi (1.5M in hexane, (iPr)2NH / 1) THF, 0 deg C, 15 min, 2) THF, -78 deg C, 30 h

3: 92 percent / NaBH₄ / tetrahydrofuran; methanol / 0 deg C, 2 h; RT, 14.5 h

4: 1) NaH / 1) THF, reflux, 30 min, 2) THF, RT, 24 h then reflux, 1 h and overnight, RT

5: 63 percent / diethyl ether

With sodium tetrahydroborate; n-butyllithium; bromine; sodium hydride; diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1002/hlca.19980810313