3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Base Information

• Chemical Name: 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate
• CAS No.: 833447-56-6
• Molecular Formula: C₆₁H₅₉N₇O₁₁
• Molecular Weight: 1066.18

Synonyms:3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Chemical Property of 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

There total 5 articles about 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

succinic acid anhydride (108-30-5) + 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine (833447-54-4) → 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-56-6)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2004.10.023

Reference yield:

N-Fmoc L-Phe (35661-40-6) → 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / N-hydroxysuccinimide; EDCI / dimethylformamide / 0 - 20 °C

2: 86 percent / pyridine; triethylamine / 3 h / 20 °C

3: 65 percent / 4-(dimethylamino)pyridine; pyridine / 24 h / 20 °C

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.10.023

Reference yield:

3'-amino-3'-deoxy-N6,N6-dimethyladenosine (58-60-6) → 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / N-hydroxysuccinimide; EDCI / dimethylformamide / 0 - 20 °C

2: 86 percent / pyridine; triethylamine / 3 h / 20 °C

3: 65 percent / 4-(dimethylamino)pyridine; pyridine / 24 h / 20 °C

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.10.023

upstream raw materials:

succinic acid anhydride

3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine

4,4'-dimethoxytrityl chloride

N-Fmoc L-Phe

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 833447-56-6 3'-amino-3'-deoxy-3'-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send