3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

Base Information

Chemical Name:3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate
CAS No.:1344998-44-2
Molecular Formula:C₂₄H₂₆ClN₃O₃S*H₂O₄S
Molecular Weight:570.087
Hs Code.:

Synonyms:3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

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Chemical Property of 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

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Technology Process of 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

There total 10 articles about 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344995-70-5
1-{[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]methyl}-3-azetidinecarboxylic acid

: 1344998-44-2
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

Guidance literature:: With sulfuric acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1344998-44-2
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C

2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C

2.2: 2 h / -10 - 20 °C

2.3: 0.17 h / 0 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Sealed vial; Microwave irradiation

6.1: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

6.2: 2 h

7.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

7.2: pH ~ 2

7.3: 20 °C / pH ~ 10

8.1: sulfuric acid / water; tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; potassium phosphate; n-butyllithium; sulfuric acid; water; isopropylmagnesium bromide; potassium acetate; sodium acetate; acetic acid; diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1344998-44-2
3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 3 h / 75 °C

1.2: Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 130 °C / Sealed vial; Microwave irradiation

4.1: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

4.2: 2 h

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

5.2: pH ~ 2

5.3: 20 °C / pH ~ 10

6.1: sulfuric acid / water; tetrahydrofuran / 0.5 h / 20 °C

With potassium phosphate; tert.-butylnitrite; sulfuric acid; water; sodium acetate; acetic acid; sodium hydroxide; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;