Technology Process of (2'R,4R)-4-benzyl-3-(5'-benzyloxy-2'-methylpentanoyl)oxazolidin-2-one
There total 5 articles about (2'R,4R)-4-benzyl-3-(5'-benzyloxy-2'-methylpentanoyl)oxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-4-benzyl-3-(5-benzyloxy-pentanoyl)oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1.25h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at -78 ℃;
for 2.5h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1080/00397911.2011.635394
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Jones reagent / acetone / 0 - 20 °C
2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 4.75 h / -78 - 20 °C / Inert atmosphere
2.2: 4.25 h / -78 - 20 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
3.2: 2.5 h / -78 °C / Inert atmosphere
With
Jones reagent; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
In
tetrahydrofuran; acetone;
DOI:10.1080/00397911.2011.635394
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere
1.2: 23 h / 0 - 20 °C / Inert atmosphere
2.1: Jones reagent / acetone / 0 - 20 °C
3.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 4.75 h / -78 - 20 °C / Inert atmosphere
3.2: 4.25 h / -78 - 20 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
4.2: 2.5 h / -78 °C / Inert atmosphere
With
Jones reagent; sodium hexamethyldisilazane; pivaloyl chloride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine;
In
tetrahydrofuran; acetone; mineral oil;
DOI:10.1080/00397911.2011.635394
