2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE

Base Information

• Chemical Name: 2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE
• CAS No.: 447406-52-2
• Molecular Formula: C11H6 F3 N O S
• Molecular Weight: 257.236
• Hs Code.: 2934100090
• Mol file: 447406-52-2.mol

Synonyms:2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE;2-(3-ethylphenyl)thiazole-5-carbaldehyde;2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE, 95+%

Chemical Property of 2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 5.93E-05mmHg at 25°C
• Boiling Point: 346°C at 760 mmHg
• Flash Point: 163°C
• PSA: 58.20000
• Density: 1.408g/cm³
• LogP: 3.64140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Trifluoromethylphenyl)thiazole-5-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE

There total 1 articles about 2-(4-TRIFLUOROMETHYLPHENYL)THIAZOLE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-bromo-1,3-thiazole-5-carbaldehyde (464192-28-7) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (447406-52-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 80 ℃; Inert atmosphere;

DOI:10.1002/anie.201905540

Reference yield: 74.0%

8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine (37682-06-7) + 2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (447406-52-2) → 7-methoxy-3-[2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-2.3.4.5-tetrahydro-1H-benzo[d]azepine (952710-29-1)

Guidance literature:

8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine; 2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde; With acetic acid; In 1,1-dichloroethane; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; at 20 ℃; for 21h;

With sodium hydroxide; In 1,1-dichloroethane; water;

Reference yield: 65.0%

2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde (447406-52-2) + methylmagnesium bromide (75-16-1) → 1-[2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethanol (447406-57-7)

Guidance literature:

2-(4-(trifluoromethyl)phenyl)thiazole-5-carbaldehyde; methylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

upstream raw materials:

2-bromo-1,3-thiazole-5-carbaldehyde

4-trifluoromethylphenylboronic acid

Downstream raw materials:

7-methoxy-3-[2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-2.3.4.5-tetrahydro-1H-benzo[d]azepine

1-[2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethanol

2,6-bis[2-(4-trifluoromethylphenyl)thiazol-5-yl]benzo[1,2-d:4,5-d']bisthiazole

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