464192-28-7

Basic information

• Product Name: 2-Bromo-5-fomylthiazole
• Synonyms: 2-BROMO-5-FORMYLTHIAZOLE;4-BROMOTHIAZOLE-2-CARBALDEHYDE;2-Bromo-5-fomylthiazole;2-Bromo-1,3-thiazole-5-carboxaldehyde 98%;2-Bromo-1,3-thiazole-5-carboxaldehyde;2-Bromo-5-formyl-1,3-thiazole;4-Bromothiazole-2-carboxaldehyde;2-Bromothiazole-5-carboxaldehy
• CAS NO: 464192-28-7
• Molecular Formula: C₄H₂BrNOS
• Molecular Weight: 192.03
• Product Categories: Aldehydes;blocks;Bromides;Thiazoles;Aldehyde;Building Blocks;Thiazole;Organohalides
• Mol File: 464192-28-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 94-96°C
• Boiling Point: 264.9 °C at 760 mmHg
• Flash Point: 114 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.92 g/cm³
• Vapor Pressure: 0.00947mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: -0.94±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-fomylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fomylthiazole(464192-28-7)
• EPA Substance Registry System: 2-Bromo-5-fomylthiazole(464192-28-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-36-22
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• Hazardous Substances Data: 464192-28-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors.

InChI:InChI=1/C4H2BrNOS/c5-4-6-1-3(2-7)8-4/h1-2H

Upstream product

• 1003-61-8 2-aminothiazole-5-carbaldehyde 
• 687636-93-7 (2-bromothiazole-5-yl)methanol 

Downstream Products

• 726185-68-8 2-piperazin-1-yl-thiazole-5-carboxylic acid methyl ester 
• 1011-40-1 2-phenyl-1,3-thiazole-5-carbaldehyde 
• 914348-82-6 C₁₁H₉NO₂S 
• 207675-84-1 2-isopropyl-thiazole-5-carbaldehyde 
• 877385-86-9 2-cyclopropylthiazole-5-carbaldehyde 
• 60587-86-2 2-propyl-5-thiazole-carboxaldehyde 
• 933683-87-5 2-ethylthiazole-5-carbaldehyde 
• 1005-28-3 2-(dimethylamino)thiazole-5-carbaldehyde 
• 914348-80-4 2-(4-fluorophenyl)thiazole-5-carbaldehyde 
• 38401-67-1 2-formyl-5-(4-methoxyphenyl)thiophene 
• 914348-84-8 2-(3-fluorophenyl)thiazole-5-carbaldehyde 
• 1332855-91-0 C₁₀H₇BrFNS 
• 1253208-84-2 (2Z,5Z)-5-[(2-bromo(1,3-thiazol-5-yl))methylene]-2-[(4-hydroxy-2-methylphenyl)azamethylene]-1,3-thiazolidin-4-one 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

THIAZOLIDINONE DERIVATIVE

An object of the present invention is to provide thiazolidinone derivatives. More specifically, an object of the present invention is to provide novel compounds having a CDC7 inhibitory action. The present invention provides thiazolidinone derivatives represented by the formula (I) The compounds of the present invention inhibit the CDC7 protein kinase activity, and suppress cell proliferation.