[2-Chloro-5-(trifluoromethyl)phenyl]cyanamide

Base Information

Chemical Name:[2-Chloro-5-(trifluoromethyl)phenyl]cyanamide
CAS No.:21714-36-3
Molecular Formula:C₈H₄ClF₃N₂
Molecular Weight:220.581
Hs Code.:
DSSTox Substance ID:DTXSID401236246

Synonyms:[2-chloro-5-(trifluoromethyl)phenyl]cyanamide;MLPMLUYPZZEGPJ-UHFFFAOYSA-N;DTXSID401236246;AKOS011770091;Cyanamide, [2-chloro-5-(trifluoromethyl)phenyl]-;21714-36-3

Suppliers and Price of [2-Chloro-5-(trifluoromethyl)phenyl]cyanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-Chloro-5-(trifluoromethyl)phenyl]cyanamide

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:220.0015103
Heavy Atom Count:14
Complexity:245

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(F)(F)F)NC#N)Cl

Technology Process of [2-Chloro-5-(trifluoromethyl)phenyl]cyanamide

There total 3 articles about [2-Chloro-5-(trifluoromethyl)phenyl]cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 21714-35-2
1-(2-chloro-5-(trifluoromethyl)phenyl)thiourea

: 21714-36-3
N-(2-chloro-5-(trifluoromethyl)phenyl)cyanamide

Guidance literature:: With iodine; triethylamine; In ethyl acetate; at 20 ℃; for 0.166667h;
DOI:10.1021/acs.jmedchem.5b01510

Reference yield:

: 89069-95-4
N-(2-chloro-5-(trifluoromethyl)phenylcarbamothioyl)benzamide

: 21714-36-3
N-(2-chloro-5-(trifluoromethyl)phenyl)cyanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 0.33 h / 90 °C

2: iodine; triethylamine / ethyl acetate / 0.17 h / 20 °C

With iodine; triethylamine; sodium hydroxide; In water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b01510

Reference yield:

: 121-50-6
3-amino-4-chlorobenzotrifluoride

: 21714-36-3
N-(2-chloro-5-(trifluoromethyl)phenyl)cyanamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 21 h / 20 °C

2: sodium hydroxide / water / 0.33 h / 90 °C

3: iodine; triethylamine / ethyl acetate / 0.17 h / 20 °C

With iodine; triethylamine; sodium hydroxide; In water; ethyl acetate; acetone;
DOI:10.1021/acs.jmedchem.5b01510