7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

Base Information

Chemical Name:7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one
CAS No.:1349643-99-7
Molecular Formula:C₁₅H₁₆F₃NO₅S
Molecular Weight:379.357
Hs Code.:

Synonyms:7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

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Chemical Property of 7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

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Technology Process of 7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

There total 4 articles about 7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: (RS)-2-oxa-7-azaspiro[4,5]decan-1-one hydrochloride

: 94108-56-2
4-(trifluoro-methoxy)benzene-1-sulfonyl chloride

: 1349643-99-7
7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

Guidance literature:: With triethylamine; In dichloromethane; at 21 ℃;

Reference yield:

: 71381-75-4,88495-54-9,84358-12-3
N-(tert-butyloxycarbonyl)nipecotic acid

: 1349643-99-7
7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hexane; diethyl ether; methanol / 4 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 °C

3.1: ozone; oxygen / dichloromethane; methanol / 2.17 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Cooling with ice-water bath

3.3: 20 °C / Cooling

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice-water bath

4.2: pH 9

5.1: triethylamine / dichloromethane / 21 °C

With oxygen; ozone; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;

Reference yield:

: 148763-41-1
1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate

: 1349643-99-7
7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere

1.2: 5 h / -78 °C

2.1: ozone; oxygen / dichloromethane; methanol / 2.17 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Cooling with ice-water bath

2.3: 20 °C / Cooling

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice-water bath

3.2: pH 9

4.1: triethylamine / dichloromethane / 21 °C

With oxygen; ozone; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane;