5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1350324-73-0
Molecular Formula:C₁₆H₁₁BrClF₃N₂O₂
Molecular Weight:436.62
Hs Code.:

Synonyms:5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

There total 9 articles about 5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350322-56-3
2-Chloro-6-difluoromethoxy-3-fluorobenzaldehyde

: 1350324-77-4
5-bromo(2,3-2H₂)-1H-pyrrolo[2,3-b]pyridine

: 1350324-73-0
5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

: 1350324-72-9
[5-bromo(2-2H)-1H-pyrrolo[2,3-b]pyridin-3-yl][2-chloro-6-(difluoromethoxy)-3-fluorophenyl]methanol

Guidance literature:: With methanol; potassium hydroxide; at 55 ℃; for 24h; sealed tube;

Reference yield:

: 1263378-40-0
2-chloro-3-fluoro-6-methoxy-benzaldehyde

: 1350324-73-0
5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

: 1350324-72-9
[5-bromo(2-2H)-1H-pyrrolo[2,3-b]pyridin-3-yl][2-chloro-6-(difluoromethoxy)-3-fluorophenyl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

1.2: 0.83 h / 0 - 20 °C

2.1: ammonium nitrate / methanol / 16 h / Inert atmosphere; Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

4.1: water; acetic acid / 16 h / 50 °C

5.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

With ammonium nitrate; methanol; water; boron tribromide; potassium carbonate; acetic acid; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 202925-07-3
2-chloro-1-fluoro-4-methoxybenzene

: 1350324-73-0
5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

: 1350324-72-9
[5-bromo(2-2H)-1H-pyrrolo[2,3-b]pyridin-3-yl][2-chloro-6-(difluoromethoxy)-3-fluorophenyl]methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tert-butyl methyl ether; hexanes / 3 h / -78 °C

1.2: 0.75 h / -60 °C

2.1: boron tribromide / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

2.2: 0.83 h / 0 - 20 °C

3.1: ammonium nitrate / methanol / 16 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

5.1: water; acetic acid / 16 h / 50 °C

6.1: potassium hydroxide; methanol / 24 h / 55 °C / sealed tube

With ammonium nitrate; methanol; n-butyllithium; water; boron tribromide; potassium carbonate; acetic acid; potassium hydroxide; In methanol; hexanes; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;