Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane

Base Information

• Chemical Name: Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane
• CAS No.: 196957-41-2
• Molecular Formula: C₁₆H₂₄O₄Si
• Molecular Weight: 308.45
• Mol file: 196957-41-2.mol

Synonyms:Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane

Chemical Property of Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane

There total 3 articles about Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + (E)-4-(3,4,5-trimethoxyphenyl)but-3-en-2-one (19039-94-2) → Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane (196957-41-2)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00304-4

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane (196957-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaOH / ethanol; H₂O / 0.75 h / Ambient temperature

2: 95 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1016/S0040-4020(98)00304-4

Reference yield:

chloro-trimethyl-silane (75-77-4) + (E)-4-(3,4,5-trimethoxyphenyl)but-3-en-2-one (19039-94-2) → Trimethyl-[(E)-1-methylene-3-(3,4,5-trimethoxy-phenyl)-allyloxy]-silane (196957-41-2)

Guidance literature:

(E)-4-(3,4,5-trimethoxyphenyl)but-3-en-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00484

upstream raw materials:

trimethylsilyl trifluoromethanesulfonate

(E)-4-(3,4,5-trimethoxyphenyl)but-3-en-2-one

3,4,5-trimethoxy-benzaldehyde

chloro-trimethyl-silane