4-Methoxy-2-fluorobenzyl cyanide

Base Information

• Chemical Name: 4-Methoxy-2-fluorobenzyl cyanide
• CAS No.: 749934-29-0
• Molecular Formula: C9H8FNO
• Molecular Weight: 165.167
• Hs Code.: 2926909090
• Mol file: 749934-29-0.mol

Synonyms:(2-Fluoro-4-methoxyphenyl)acetonitrile;2-Fluoro-4-methoxybenzyl cyanide;

Chemical Property of 4-Methoxy-2-fluorobenzyl cyanide

Chemical Property:

• Vapor Pressure: 0.0189mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 252.8 °C at 760 mmHg
• Flash Point: 106.7 °C
• PSA: 33.02000
• Density: 1.148 g/cm³
• LogP: 1.90038

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-4-methoxyphenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-2-fluorobenzyl cyanide

There total 1 articles about 4-Methoxy-2-fluorobenzyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-fluoro-4-methoxybenzyl bromide (54788-19-1) + potassium cyanide (151-50-8) → 2-(2-fluoro-4-methoxyphenyl)acetonitrile (749934-29-0)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In dichloromethane; water; for 8h;

Reference yield: 82.0%

2-(2-fluoro-4-methoxyphenyl)acetonitrile (749934-29-0) + methyl iodide (74-88-4) → 2-(2-Fluoro-4-methoxy-phenyl)-2-methyl-propionitrile (749934-28-9)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 0 - 20 ℃; for 6h;

Reference yield: 73.4%

2-(2-fluoro-4-methoxyphenyl)acetonitrile (749934-29-0) + 1-Bromo-2-chloroethane (107-04-0) → 1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile (1282555-27-4)

Guidance literature:

2-(2-fluoro-4-methoxyphenyl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

1-Bromo-2-chloroethane; In N,N-dimethyl-formamide; mineral oil; at 0 - 30 ℃; for 3h;

upstream raw materials:

2-fluoro-4-methoxybenzyl bromide

potassium cyanide

Downstream raw materials:

2-(2-Fluoro-4-methoxy-phenyl)-2-methyl-propionitrile

1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carboxylic acid

1-(3-fluoro-4-methoxyphenyl)cyclopropane-1-carbonitrile

Refernces