1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Base Information

Chemical Name:1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole
CAS No.:882037-01-6
Molecular Formula:C₂₅H₁₇F₄N₅O₃
Molecular Weight:511.435
Hs Code.:

Synonyms:1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

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Chemical Property of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

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Technology Process of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

There total 10 articles about 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 906068-68-6
2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-trimethylsilanyloxymethyl-biphenyl-4-yl)-amide

: 882037-01-6
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: With hydrogenchloride; In ethanol; for 3h; Heating;
DOI:10.1016/j.bmcl.2006.01.010

Reference yield:

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 882037-01-6
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: 90 percent / acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide

3: 80 percent / HCl / ethanol / 3 h / Heating

With hydrogenchloride; acetylhydroxamic acid; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.01.010

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 882037-01-6
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-2'-hydroxymethyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 20 °C

2: Et₃N / CH₂Cl₂

3: 90 percent / acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide

4: 80 percent / HCl / ethanol / 3 h / Heating

With hydrogenchloride; thionyl chloride; acetylhydroxamic acid; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.01.010