2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Base Information

Chemical Name:2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester
CAS No.:524956-60-3
Molecular Formula:C₃₅H₄₈O₇Si
Molecular Weight:608.847
Hs Code.:

Synonyms:2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Suppliers and Price of 2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

There total 8 articles about 2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-59-8
malonic acid dimethyl ester

: 524956-58-9
tert-butyl-(12-chloro-7-methoxymethoxydodeca-(2Z,8E,10Z)-trienyloxy)diphenylsilane

: 524956-60-3
2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Guidance literature:: malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

tert-butyl-(12-chloro-7-methoxymethoxydodeca-(2Z,8E,10Z)-trienyloxy)diphenylsilane; With sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1139/v02-064

Reference yield:

: 119119-20-9
(2E,4Z)-6-(Tetrahydro-pyran-2-yloxy)-hexa-2,4-dienal

: 524956-60-3
2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert-butyllithium / diethyl ether / 0.17 h / -78 °C

1.2: 92 percent / diethyl ether / 0.42 h / -78 - 20 °C

2.1: 97 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran / 2 h / 0 - 70 °C

3.1: 81 percent / pyridinium p-toluenesulfonate / propan-2-ol / 1 h / Heating

4.1: 91 percent / hexachloroacetone; triphenylphosphine / CH₂Cl₂ / 20 °C

5.1: sodium hydride / dimethylformamide; tetrahydrofuran / 20 °C

5.2: 89 percent / sodium iodide / tetrahydrofuran; dimethylformamide / 70 °C

With 1,1,1,3,3,3-hexachloro-propan-2-one; tert.-butyl lithium; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1139/v02-064

Reference yield:

: 307497-58-1
(4Z)-6-(tert-butyldiphenylsilyloxy)-4-hexen-1-ol

: 524956-60-3
2-[12-(tert-butyldiphenylsilanyloxy)-6-methoxymethoxydodeca-(2Z,4E,10Z)-trienyl]malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

2.1: 15.14 g / sodium iodide / acetone / 1.5 h / Heating

3.1: tert-butyllithium / diethyl ether / 0.17 h / -78 °C

3.2: 92 percent / diethyl ether / 0.42 h / -78 - 20 °C

4.1: 97 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran / 2 h / 0 - 70 °C

5.1: 81 percent / pyridinium p-toluenesulfonate / propan-2-ol / 1 h / Heating

6.1: 91 percent / hexachloroacetone; triphenylphosphine / CH₂Cl₂ / 20 °C

7.1: sodium hydride / dimethylformamide; tetrahydrofuran / 20 °C

7.2: 89 percent / sodium iodide / tetrahydrofuran; dimethylformamide / 70 °C

With 1,1,1,3,3,3-hexachloro-propan-2-one; tert.-butyl lithium; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1139/v02-064