(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

Base Information

Chemical Name:(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide
CAS No.:627859-95-4
Molecular Formula:C₃₈H₄₈N₂O₄Si
Molecular Weight:624.896
Hs Code.:

Synonyms:(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

Suppliers and Price of (2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

There total 1 articles about (2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 627859-94-3
(S)-4-Benzyl-3-[(2S,3S,4R)-5-(tert-butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoyl]-oxazolidin-2-one

: 627859-95-4
(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In tetrahydrofuran; at -30 ℃;

(S)-4-Benzyl-3-[(2S,3S,4R)-5-(tert-butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoyl]-oxazolidin-2-one; In tetrahydrofuran; at 0 ℃; for 2.5h;
DOI:10.1016/j.tetlet.2003.08.030

Reference yield: 65.0%

: 627859-95-4
(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

: 627859-93-2
(3S,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-methyl-pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 72h;
DOI:10.1016/j.tetlet.2003.08.030

Reference yield:

: 627859-95-4
(2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-3-hydroxy-2-methyl-pentanoic acid methoxy-methyl-amide

: 627860-06-4
4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / H₂ / Pd(OH)2 / methanol / 72 h / 20 °C

2: 94 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

With 2,6-dimethylpyridine; hydrogen; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2003.08.030